Faculty

Jonathan (Jon) G. RudickJonathan (Jon) G. Rudick
Assistant Professor

B.S. Case Western Reserve University (2000)
Ph.D. University of Pennsylvania (2005)
Scientist, Procter & Gamble (2005-2007)
NIH Postdoctoral Fellowship, University of Pennsylvania, School of Medicine (2007-2010)

775 Chemistry
Phone: (631) 632-7630
Email:

The Rudick Group Website

Organic, Supramolecular, and Polymer Chemistry

Our research aims to create atomically precise nanostructures and nanostructured materials through a combination of synthesis and self-assembly. Such well-defined structures are considered platforms from which to develop materials for energy, electronic, and biological applications. Our approach focuses on molecular architecture as a source of complexity from which to obtain unprecedented properties.

Dendron-Peptide Biohybrid Materials

We are pursuing a strategy to control hierarchical structure from the molecular to nanometer scales by combining self-assembling peptides and amphiphilic dendrons. These biohybrid materials are designed to retain the protein-like three-dimensional structure of the peptides while taking advantage of the bulk self-organization of the dendrons.

Surface-Multiblock Dendrimers

Dendrimers are highly branched, monodisperse macromolecules that present a large number of equivalent functional groups. To better control the properties of dendrimers for applications in drug delivery and supramolecular materials, it is desirable to precisely tailor the surface functional group composition of dendrimers. We have demonstrated that isocyanide multicomponent reactions yield dendrimers with clusters of different functional groups for tailoring the properties of the dendrimer. This technology is being further developed to explore the properties of novel surface-multiblock dendrimers.

Publications

  1. 1. J.-A. Jee, L. A. Spagnuolo & J. G. Rudick. “Convergent synthesis of dendrimers via the Passerini three-component reaction.” Org. Lett. 2012, 14, 3292-3295. (DOI: 10.1021/ol301263v)
  2. 2. J. G. Rudick & V. Percec. “Nanomechanical function made possible by suppressing structural transformations of polyarylacetylenes.” Macromol. Chem. Phys. 2008, 209, 1759–1768. (DOI: 10.1002/macp.200800271)
  3. 3. J. G. Rudick & V. Percec. “Induced helical backbone conformations of self organizable dendronized polymers.” Acc. Chem. Res. 2008, 41, 1641–1652. (DOI: 10.1021/ar800086w)
  4. 4. V. Percec, J. G. Rudick, M. Peterca & P. A. Heiney. “Nanomechanical function from self–organizable dendronized helical polyphenylacetylenes.” J. Am. Chem. Soc. 2008, 130, 7503–7508. (DOI: 10.1021/ja801863e)
  5. 5. V. Percec, J. G. Rudick, M. Peterca, M. E. Yurchenko, J. Smidrkal & P. A. Heiney. “Supramolecular structural diversity among first generation hybrid dendrimers and twin–dendrons.” Chem. – Eur. J. 2008, 14, 3355–3362. (DOI: 10.1002/chem.200701658)
  6. 6. V. Percec, M. Peterca, M. E. Yurchenko, J. G. Rudick & P. A. Heiney. “Thixotropic twin–dendritic organogelators.” Chem. – Eur. J. 2008, 14, 909–918. (DOI: 10.1002/chem.200701273)
  7. 7. V. Percec, M. Peterca, J. G. Rudick, E. Aqad, M. R. Imam & P. A. Heiney. “Self–assembling phenylpropyl ether dendronized helical polyphenylacetylenes.” Chem. – Eur. J. 2007, 13, 9572–9581. (DOI: 10.1002/chem.200701008)
  8. 8. V. Percec, J. G. Rudick, M. Peterca, E. Aqad, M. R. Imam & P. A. Heiney. “Synthesis, structural and retrostructural analysis of helical dendronized poly(1 naphthylacetylene)s.” J. Polym. Sci., Part A: Polym. Chem. 2007, 45, 4974–4987. (DOI: 10.1002/pola.22265)
  9. 9. J. G. Rudick & V. Percec. “Helical chirality in dendronized polyarylacetylenes.” New J. Chem. 2007, 31, 1083–1096. (DOI: 10.1039/b616449h)
  10. 10. V. Percec, E. Aqad, M. Peterca, J. G. Rudick, L. Lemon, J. C. Ronda, B. B. De, P. A. Heiney & E. W. Meijer. “Steric communication of chiral information observed in amphiphilic dendronized polyacetylenes.” J. Am. Chem. Soc. 2006, 128, 16365–16372. (DOI: 10.1021/ja0665848)
  11. 11. V. Percec, J. G. Rudick, M. Wagner, M. Obata, C. M. Mitchell, W.–D. Cho & S. N. Magonov. "AFM Visualization of individual and periodic assemblies of a helical dendronized polyphenylacetylene on graphite." Macromolecules 2006, 39, 7342–7351. (DOI: 10.1021/ma060845g)
  12. 12. V. Percec, J. G. Rudick, M. Peterca, S. R. Staley, M. Wagner, M. Obata, C. M. Mitchell, W.–D. Cho, V. S. K. Balagurusamy, J. N. Lowe, M. Glodde, O. Weichold, K. J. Chung, N. Ghionni, S. N. Magonov & P. A. Heiney. "Synthesis, structural analysis, and visualization of a library of dendronized polyphenylacetylenes." Chem. – Eur. J. 2006, 12, 5731–5746. (DOI: 10.1002/chem.200600009)
  13. 13. V. Percec, J. G. Rudick, M. Peterca, M. Wagner, M. Obata, C. M. Mitchell, W.–D. Cho, V. S. K. Balagurusamy & P. A. Heiney. "Thermoreversible cis–cisoidal to cis–transoidal isomerization of helical dendronized polyphenylacetylenes." J. Am. Chem. Soc. 2005, 127, 15257–15264. (DOI: 10.1021/ja055406w)
  14. 14. V. Percec, J. G. Rudick & E. Aqad. "Diminished helical character in para–substituted cis–transoidal polyphenylacetylenes due to intramolecular cyclization." Macromolecules 2005, 38, 7205–7206. (DOI: 10.1021/ma051536d)
  15. 15. V. Percec & J. G. Rudick. "Independent electrocyclization and oxidative chain cleavage along the backbone of cis–poly(phenylacetylene)." Macromolecules 2005, 38, 7241–7250. (DOI: 10.1021/ma051060y)
  16. 16. V. Percec, M. Obata, J. G. Rudick, B. B. De, M. Glodde, T. K. Bera, S. N. Magonov, V. S. K. Balagurusamy & P. A. Heiney. "Synthesis, structural analysis, and visualization of poly(2–ethynyl–9–substituted carbazole)s and poly(3–ethynyl–9–substituted carbazole)s containing chiral and achiral minidendritic substituents." J. Polym. Sci., Part A: Polym. Chem. 2002, 40, 3509–3533. (DOI: 10.1002/pola.10458)
  17. 17. V. Percec, J. G. Rudick, P. Nombel & W. Buchowicz. "Dramatic decrease of the cis–content and molecular weight of cis–transoidal polyphenylacetylene at 23 ºC in solutions prepared in air." J. Polym. Sci., Part A: Polym. Chem. 2002, 40, 3212–3220. (DOI: 10.1002/pola.10421)

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