Liang GaoLiang Gao, Assistant Professor

B.S. Tsinghua University, Beijing, China, 2000
M.S. Tsinghua University, Beijing, China, 2003
Ph.D. Purdue University, West Lafayette, IN, 2009

567 Chemistry
Phone: (631) 632 8572 | Fax: (631) 632 7960

Professional Preparation

Tsinghua University, China Precision Instrument B.S., 2000
Tsinghua University, China Precision Instrument M.S., 2003
Purdue University, Analytical Chemistry Ph.D., 2009


2014-present Assistant Professor, Department of Chemistry and Department of Biochemistry & Cell Biology, Stony Brook University, Stony Brook, NY

2009-2013   Research Associate, Janelia Farm Research Campus, Howard Hughes Medical Institute, Ashburn, VA

Awards and Fellowships

2012 Marine Biological Laboratory Physiology Course, NIH grant
2011 Olympus Bioscapes Competition, the Third Prize
2009-2010 American Chemical Society, Division of Analytical Chemistry, Graduate Fellowship Award sponsored by Agilent Technologies
2009 Harsh-Environment Mass Spectrometry (HEMS) workshop student travel award


L. Gao, “Extend the field of view of selective plane illumination microscopy by tiling the excitation light sheet”, Optics Express, 23(5),6102-6111 (2015)

L. Gao, “Optimization of the excitation light sheet in selective plane illumination microscopy”, Biomedical Optics Express, 6(3), 881-890 (2015)

Wang, D., Meza, D. Wang, Y. Gao, L., Liu, J.T.C. (2014) “Sheet-scanned dual axis confocal (SS-DAC) microscopy using Richardson-Lucy deconvolution”, Optics Letters, 39, 5431-5434

Gao, L.,* Shao, L., Chen, B.C., Betzig, E. (2014) “3D Live Fluorescence Imaging of Cellular Dynamics Using Bessel Beam Plane Illumination Microscopy”, Nature Protocols, 9, 1083-1011. (*Corresponding Author, Cover article)

Gao, L., Shao, L., Higgins, D.C., Poulton, J.S., Peifer, M., Davidson, M.D., Wu, X., Goldstein, B., and Betzig, E. (2012) “Noninvasive imaging of 3D dynamics in thickly fluorescent specimens beyond the diffraction limit”, Cell, 6, 1370-1385.

Planchon, T.A.,* Gao, L.,* Milkie, D.E., Davidson, M.W., Galbraith, J.A., Galbraith, C.G., Betzig, E. (2011) “Rapid three-dimensional isotropic imaging of living cells using Bessel beam plane illumination”, Nature Methods, 8, 417-423. (*Equal Contribution, Cover article)

Majoul, I., Gao, L., Eric Betzig, Onichtchouk, D., Butkevich, E., Kozlov, Y., Bukauskas, F., Bennett, M.V.L., Lippincott-Schwartz, J., Duden, R. (2013) “Fast structural responses of gap junction membrane domains to AB5 toxins”, Proceedings of the National Academy of Sciences, 110(44), E4125-33.

Roh-Johnson, M., Shemer, G., Higgins, C.D., McClellan, J.H., Werts, A.D., TuLu, U.S., Gao, L., Betzig, E., Kiehart, D.P., Goldstein, B. (2012) “Triggering  a cell shape changes by exploiting pre-existing actomyosin constractions”, Science, 335, 1232-1235.

Legant, W.L., Choi, C.K., Miller, J.S., Shao, L., Gao, L., Betzig, E., Chen, C.S. (2012) “Multidimensional traction force microscopy reveals rotational moments about focal adhesions”, Proceedings of the National Academy of Sciences, 110(3), 881-886.

Gao, L., Li, G., Cooks, R.G. (2010) “Axial CID and high pressure resonance CID in a miniature ion trap mass spectrometer using a discontinuous atmospheric pressure interface”, Journal of The American Society for Mass Spectrometry, 21, 209-214.

Gao, L., Li, G., Cyriac, J., Nie, Z., Cooks, R.G. (2010) “Imaging of surface charge and the mechanism of desorption electrospray ionization mass spectrometry”, Journal of Physical Chemistry C, 114, 5331-5337.

Gao, L., Li, G., Nie, Z., Duncan, J., Ouyang, Z., Cooks, R.G. (2009) “Characterization of a discontinuous atmospheric pressure interface. Multiple ion introduction pulses for improved performance”, International Journal of Mass Spectrometry, 283, 30-34.

Gao, L., Sugiarto, A., Harper, J.D., Cooks, R.G., Ouyang, Z. (2008) “Design and characterization of a multisource hand-held mass spectrometer”, Analytical Chemistry, 80, 7196-7205. (Accelerated Article, Cover article)

Gao, L., Cooks, R.G., Ouyang, Z. (2008) “Breaking the pumping speed barrier in mass spectrometry: Discontinuous Atmospheric Pressure Interface”, Analytical Chemistry, 80, 4026-4032.

Gao, L., Song, Q., Noll, R.J., Duncan, J., Cooks, R.G., Ouyang, Z. (2007) “Glow discharge electron impact ionization source for miniature mass spectrometers”, Journal of Mass Spectrometry, 42, 675-680.

Gao, L., Song, Q., Patterson, G.E., Cooks, R.G., Ouyang, Z., (2006) “Handheld rectilinear ion trap mass spectrometer”, Analytical Chemistry, 78, 5994-6002. (Accelerated Article)

Cyriac, J., Wleklinski, M., Li, G., Gao, L., Cooks, R.G. (2012) “In situ Raman spectroscopy of surfaces by ion soft landing”, Analyst, 137, 1363-1369.

Li, G., Cyriac, J., Gao, L., Cooks, R.G. (2011) “Molecular ion yield enhancement in static secondary ion mass spectrometry by soft landing of protonated water clusters”, Surface and Interface Analysis, 43, 498-501.

Clare, A.T., Gao, L., Brkić, B., Paul R. Chalker, Taylor, S. (2010) “Linear ion trap fabricated using rapid manufacturing technology”, Journal of The American Society for Mass Spectrometry, 21, 317-322.

Song, Q., Xu, W., Smith, S.A., Gao, L., Chappell, W.J., Cooks, R.G., Ouyang, Z. (2010) “Ion trap mass analysis at high pressure: an experimental characterization”, Journal of Mass Spectrometry, 45, 26-34.

Huang, G., Gao, L., Duncan, J., Harper, J.D., Sanders, N.L., Ouyang, Z., Cooks, R.G. (2010) “Direct detection of benzene, toluene, and ethylbenzene at trace levels in ambient air by atmospheric pressure chemical ionization Using a handheld mass spectrometer”, Journal of The American Society for Mass Spectrometry, 21, 132-135.

Nie, Z., Guangtao Li, Goodwin, M., Gao, L., Cyriac, J., Cooks, R.G. (2009) “In situ SIMS Analysis and Reactions of Surfaces Prepared by Soft-Landing of Mass-selected Cations and Anions using an Ion Trap Mass Spectrometer”, Journal of American Society for Mass Spectrometry, 20, 949-956.

Song, Q., Smith, S.A., Gao, L., Xu, W., Volny, M., Ouyang, Z., Cooks, R.G. (2009) “Mass Selection of Ions from Beams Using Waveform Isolation”, Analytical Chemistry, 81, 1833-1840.

Keil, A., Hernandez-Soto, H., Noll, R.J., Fico, M., Gao, L., Ouyang, Z., Cooks, R.G. (2008) “Monitoring of toxic compounds in air using a handheld rectilinear mass spectrometer”, Analytical Chemistry, 80, 734-741.

Keil, A., Talaty, N., Janfelt, C., Noll, R.J., Gao, L., Ouyang, Z., Cooks, R.G. (2007) “Ambient mass spectrometry with a handheld mass spectrometer at high pressure”, Analytical Chemistry, 42, 675-680.

Ouyang, Z., Gao, L., Fico, M., Chappell, W.J., Noll, R.J., Cooks, R.G. (2007) “Quadrupole ion traps and trap arrays: geometry, material, scale, performance”, European Journal of Mass Spectrometry, 13, 13-18.


Zheng Ouyang, Liang Gao, R. Graham Cooks, “Discontinuous Atmospheric Pressure Interface”, US Patent (US 8304718 B2).

Research Highlights

  1. Nature Methods, “Bessel beams beyond the limit”, 2013, 10
  2. Nature, “Seeing cells with sheets of light”, 2011, 471, 268.
  3. Nature Biotechnology, “Bessel beams for light relief”, 2011, 29(4).
  4. Nature Methods, “Imaging life with thin sheets of light”, 2012, 9(1).
  5. HHMI News, “New microscope produces dazzling 3D movies of live cells”, March 04, 2011.
  6. Chemical & Engineering News / Science & Technology / Concentrates, “Interface boosts MS performance”, May 19, 2008, 86(20), 39-40.
  7. Chemical & Engineering News / Cover Story, “Better than ever at Pittcon 2006”, April 3, 2006, 84(14), 45-51.
  8. National Science Foundation / News, “Small ultra-fast and ultra-versatile scanner takes chemical analysis to the field” video interview for schools use, March 16, 2006.